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MotoGP World Standing Misano 2010
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| Pos. | Rider | Bike | Nation | Points |
| 1 | Jorge LORENZO | Yamaha | SPA | 271 |
| 2 | Dani PEDROSA | Honda | SPA | 208 |
| 3 | Andrea DOVIZIOSO | Honda | ITA | 139 |
| 4 | Valentino ROSSI | Yamaha | ITA | 130 |
| 5 | Casey STONER | Ducati | AUS | 130 |
| 6 | Ben SPIES | Yamaha | USA | 120 |
| 7 | Nicky HAYDEN | Ducati | USA | 109 |
| 8 | Randy DE PUNIET | Honda | FRA | 81 |
| 9 | Marco MELANDRI | Honda | ITA | 67 |
| 10 | Colin EDWARDS | Yamaha | USA | 66 |
| 11 | Marco SIMONCELLI | Honda | ITA | 65 |
| 12 | Hector BARBERA | Ducati | SPA | 61 |
| 13 | Aleix ESPARGARO | Ducati | SPA | 44 |
| 14 | Alvaro BAUTISTA | Suzuki | SPA | 41 |
| 15 | Loris CAPIROSSI | Suzuki | ITA | 41 |
| 16 | Mika KALLIO | Ducati | FIN | 31 |
| 17 | Hiroshi AOYAMA | Honda | JPN | 26 |
| 18 | Alex DE ANGELIS | Honda | RSM | 11 |
| 19 | Roger Lee HAYDEN | Honda | USA | 5 |
| 20 | Kousuke AKIYOSHI | Honda | JPN | 4 |
| 21 | Wataru YOSHIKAWA | Yamaha | JPN | 1 |
